Preparation of acetylsalicylic acid aspirin background one of the most widely used nonprescription drugs is aspirin. Aspirin is one of the milder and least expensive pain relievers available. Synthesis of aspirin aspirin is the single most manufactured drug in the world. Aspirin acetylsalicylic acid is a painrelieving compound familiar to virtually all students. Specific inflammatory conditions which aspirin is used to treat include kawasaki disease, pericarditis, and rheumatic fever. H 2 so 4 use a dropper, h 2 so 4 is highly corrosive and swirl the flask gently until the salicylic acid dissolves heat the flask gently on the steam bath for at least 10 minutes. Calculate the percent yield of aspirin amount collected theoretical yield x 100% what is the melt point of your dried aspirin. The polar oxygen accepts the electrons from now positively charged hydrogen. Aspirin given shortly after a heart attack decreases the risk of death. Aspirins chemical name is acetylsalicyl ic acid, and it is synthesized from the reaction of acetic anhydride with salicylic acid in the presence of phosphoric acid as. To verify the identity of the aspirin, completely dissolve. This is not surprising when one considers the medicinal applications for aspirin. Calculate the mass of crude aspirin that you collected.
The purpose of this experiment is to synthesize a common organic product called acetylsalicylic acid aspirin, and to become familiar with the optimum conditions needed for successful yields. You have been asked to evaluate a simple organic synthesis for aspirin and to determine if the synthesis merits further funding by santa monica pharmaceuticals. Synthesis of aspirin introduction aspirin is one of the milder and least expensive pain relievers available. Synthesis of aspirin report data collected and subsequent calculations to all equipment should be returned to the correct location after use. Synthesis and analysis of acetyl salicylic acid amy chan chem 290 section 1 november 25, 2002. This paper describes the first of our organic synthesis experiments, the synthesis, purification, and qualitative spectroscopic characterization of aspirin. One of the most consumed drugs production in the us is 10 million kgyear aspirin. Synthesis of aspirin ppt green chemistry filtration.
Pdf preparing a pure aspirin acetylsalicylic acid researchgate. Your team of scientists has been hired by the drug research division of santa monica. Aspirin synthesis tap water was heated on a steam bath in a 250 ml beaker. Synthesis of aspirin ppt free download as powerpoint presentation. Synthesis of aspirin and oil of wintergreen the purpose of this experiment was to employ techniques to synthesize aspirin and oil of wintergreen and to purify crude aspirin via recrystallization. Heating should be continued until the solution is clear. Pdf the synthesis and analysis of aspirin semantic scholar. Theory aspirin, acetylsalicylic acid, was first synthesized in 1893 by felix hofmann, a chemist for the german firm of bayer. The synthesis and characterization of aspirin part 1 purpose. Prostaglandins were found to be responsible for pain and blood clotting. The synthesis of aspirin from oil of wintergreen is an example of one of. Synthesis of aspirin adapted from bettelheim objective. The synthesis of aspirin chemistry science fair project. Synthesizing aspirin and oil of wintergreen purpose in this experiment, you will synthesize acetylsalicylic acid, commonly known as aspirin, and methyl salicylate, oil of wintergreen, from salicylic acid.
The antiplatelet activity of aspirin has resulted in a new use for an old drug. Synthesis of aspirin lab report 1101 words 5 pages. Allow the flask to stand at room temperature until. Compound molecular weight hazards density melting point salicylic acid 8. In the presence of moisture, aspirin may decompose hydrolysis into salicylic acid and acetic acid. After synthesis and analysis, it will be determined if the crude and recrystallized samples were composed solely of either salicylic acid, acetylsalicylic acid, or a combination of both 3. Antiinflammatory inhibition of the synthesis of prostaglandins. The temperature of an alcohol thermometer was equilibrated in a beaker of room temperature tap water. Please attribute this work as being created by the north c. To synthesize acetylsalicylic acid aspirin, purify it, and determine the percent yield.
Tinjauan pustaka esterifikasi adalah reaksi pengubahan dari suatu asam. Organic synthesis of aspirin chemistry formal lab essay sample. Aspirin, also known as acetylsalicylic acid asa, is a medication used to reduce pain, fever, or inflammation. Jeana greaves chem3301112 june 19, 20 synthesis of aspirin from methyl salicylate introduction the synthesis of aspirin acetyl salicyclic acid began with methyl salicylate and sodium hydroxide as the reagent. Aspirin is one of the most widely used nonprescription drugs in the world, with over 50 million pounds consumed annually. Synthesis in this experiment, aspirin will be produced by reacting salicylic acid with acetic anhydride, a derivative of acetic acid that has similar chemicals properties to acetic acid, but reacts more rapidly and efficiently. Since acetic acid is very soluble in water, it is easily separated from the aspirin product. This compound had the medicinal properties of salicylic acid, an extract of willow bark. This reaction is the reverse of the synthesis reaction. Organic synthesis of aspirin chemistry formal lab essay. Synthesis of salicylic acid from oil of wintergreen. Aspirin is an analgesic pain reliever, an antipyretic fever reducer, and antiinflammatory medicine.
The synthesis of aspirin chemistry science fair project experiments, chemistry models, exhibition ideas, expo topics for kids and also organics chemistry science ideas for cbse, icse, middleschool, elementary school for 5th, 6th, 7th, 8th, 9th and high school students. The purity of the product will be confirmed by measuring its melting point range. In this experiment, you will measure the melting point of your synthesized asa product, salicylic acid, a crushed aspirin tablet, and pure asa from a manufacturer. An experiment is described that is suitable for the early portion of the laboratory in a general chemistry course and integrates organic examples. Store the aspirin in the desicooler and determine the percent yield of the synthesis by taking the actual yield and dividing it by the theoretical yield, determined from the original amount of salicylic acid used. To determine the purity of the aspirin or acetaminophen. A greener approach to aspirin synthesis using microwave irradiation. To become familiar with the role of synthetic chemistry through the production of aspirin. Performs the synthesis of acetylsalicylic acid aspirin purification by recrystallization and using melting point to confirm identity. Chan 1 introduction acetyl salicylic acid, commonly known as aspirin, is one of the most common synthetic medicines. Synthesis of aspirin background aspirin, which ranks as the most widely used drug in the united states, is one of a series of salicylic acid esters that has been known since antiquity to have therapeutic effects. Though aspirin has numerous benefits, there are several adverse affects as well.
Tujuan percobaan memahami reaksi esterifikasi fenol memahami reaksi pembuatan aspirin mampu melakukan uji kadar aspirin hasil reaksi 2. Aspirin is a drug which is widely used today to deal with the symptoms of many minor illnesses ranging from general relief from aches and pain. One of the most widely used nonprescription drugs is aspirin. Aspirin acetylsalicylic acid is the most common medicinal drug in use today. The synthesis of aspirin has been a popular experiment in organic chemistry teaching laboratories and even in some introductory chemistry laboratories 1. Experiment 8 synthesis of aspirin aspirin is an effective analgesic pain reliever, antipyretic fever reducer and antiinflammatory agent and is one of the most widely used nonprescription drugs. Aspirins chemical name is acetylsalicylic acid, and it is synthesized from the reaction of acetic anhydride with salicylic acid in the presence of phosphoric acid as a catalyst. Pdf this aim of this experiment focuses on the synthesis of pure aspirin acetylsalicylic acid from ethanoic anhydride and salicylic acid while. Over the course of the first semester and the beginning of the second, our general chemistry students synthesize two organic substances aspirin and methyl. You will be able to see how two very different organic compounds can be made from the same common starting material. Aspirin alters the oxygenase activity of prostaglandin synthetase by moving the acetyl group to a terminal amine group4. The reaction that is used for the synthesis is shown below. Synthesis of aspirin lab report and analysis odinity.
Aspirin may help to decrease the progression of athero. In the united states, more than 15,000 pounds are sold each year. Preparation, purification and analysis of aspirin acetylsalicylic acid. Aspirin is superior to salicylic acid for oral dosage in that the latter is very bitter, and causes stomach. Synthesis of aspirin experiment chemistry libretexts. First discovered in 1897 by felix hoffman, it has since been used in over 50 overthecounter medicines. In june 1971 nature published a seminal paper by john vane and priscilla piper, inhibition of prostaglandin synthesis as a mechanism of action for aspirinlike drugs. Waste salicylic acid should be disposed of in the solid waste container. The synthesis and characterization of aspirin part 1.
Compare the melting points of your aspirin and pure aspirin. The mechanism for this synthesis provides examples of three major classes of chemical reactions. This experiment will demonstrate the preparation of aspirin. Aspirin synthesis your team of scientists has been hired by the drug research division of santa monica pharmaceuticals, a new startup company formed by some smc alumni. Company replaced the phenol group with an ester group. In fact, many cultures have used plants containing significant amounts of these compounds in medications to relieve. This figure mainly reflects purchase of 16,000 tons of aspirin tablets or 80 million tablets a year. As a current student on this bumpy collegiate pathway, i stumbled upon course hero, where i can find study resources for nearly all my courses, get online help from tutors 247, and even share my old projects, papers, and lecture notes with other students. Synthesis of aspirin synthesis purification characterization. We will prepare aspirin by reacting salicylic acid 1 with an excess of acetic. This aim of this experiment focuses on the synthesis of pure aspirin acetylsalicylic acid from ethanoic anhydride and salicylic acid while using concentrated sulfuric acid as a catalyst for the. The use of aspirin had its origin in the 18th century, when it was found that an extract from the. Synthesis of aspirin lab report 2989 words bartleby. It is the twostep synthesis of aspirin starting from oil of wintergreen.
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